With the global spread of 5G networks, multi-antenna technology has become a core element to promote the development of wireless communication systems. This paper analyzes the application of multi-antenna technology in 5G wireless communication, such as base station and user end point deployment, network performance, communication security, resource management, etc. Through the discussion of large-scale MIMO, beamforming technology and quota algorithm, this paper emphasizes the important role of multi-antenna technology in increasing data transmission speed, reducing communication delay, expanding network coverage and strengthening communication security.