Instrument and control of water supply and drainage engineering is a multi-disciplinary course. With the continuous improvement of automation and digitalization,The traditional classroom teaching methods and assessment methods have been difficult to meet the needs of the industry. This paper adopts various measures such as online and offline blended teaching to carry out teaching reform, which stimulates students? enthusiasm and initiative, pays attention to theory and practice, improves students? interest in learning, cultivates students? innovation ability and collaboration ability, and improves teaching effect.