As an important base for power production, the safety production of thermal power plants is directly related to the peoples livelihood. This paper aims to explore the construction plan and specific application of intelligent safety production supervision center in thermal power plants, in order to improve the safety production management level of thermal power plants. By constructing an intelligent supervision platform based on information systems, combined with key technologies such as intelligent video monitoring, personnel positioning and management, and intelligent robot inspection, real-time monitoring and early warning of the entire production process of thermal power plants have been achieved, effectively improving safety production efficiency. This paper also analyzes the specific application cases of the Intelligent Safety Production Supervision Center in thermal power plants, providing useful references for the future intelligent transformation of thermal power plants.