In order to ensure the stable transmission and high-quality reception of radio and television transmitter signals, the research on interference suppression of radio and television transmitter signals is carried out by using fast Fourier transform. Firstly, the radio and television transmitter signals are continuously collected by using high-speed data collection cards, and then denoised and calibrated. Secondly, the interference signals in the transmitter signals are identified by using fast Fourier transform. On this basis, the existence of asynchronous signals is analyzed, and the interference suppression is achieved by Bayesian processing. The experimental results show that after applying this method, the maximum bit error rate of radio and television transmitter signals does not exceed 0.04, which has good results.