In order to improve the stability and reliability of hospital information system in clinical application, this paper proposes a hospital information system operation and maintenance technology based on clinical visits. First, establish a system operation status evaluation model, monitor the operation status of each module of the system in real time, and identify potential failure hazards in the system. Secondly, design an inspection algorithm, use mobile end point equipment to collect system operation data regularly, and combine expert experience to analyze and warn abnormalities. Finally, automatically repair and record the discovered failure hazards to ensure the continuous and stable operation of the hospital information system. The experimental results show that after applying the patrol maintenance technology, the system failure rate is significantly reduced, the system response speed is gradually improved, and the overall maintenance effect is better than that of the traditional method.