This paper discusses the application of cloud computing technology in the operation of pharmaceutical equipment, aiming to improve the operation efficiency of pharmaceutical equipment, reduce the failure rate, and ensure the safety and stability of the drug production process. First, establish an equipment data collection and monitoring system based on cloud computing to realize real-time monitoring and data transmission of the operation status of pharmaceutical equipment. Secondly, use the computing power of the cloud platform to analyze and process the operation data of pharmaceutical equipment to identify potential faults. Finally, provide remote maintenance suggestions and troubleshooting solutions through the cloud platform. The experimental results show that the application of cloud computing technology can not only improve the efficiency and stability of pharmaceutical equipment operation， but also effectively reduce manual intervention and ensure the production quality of drugs.