This paper discusses the challenges and countermeasures of university library information retrieval service under the mobile terminal environment. With the popularization of mobile Internet, university libraries face many challenges such as technology, resources, services and users. This paper analyzes the problems of mobile network stability, device compatibility, lack of resource integration and lack of personalized service, and puts forward countermeasures such as technology upgrading, resource integration, service innovation and user education. The aim is to improve the efficiency and quality of information retrieval service of university library, meet the diversified needs of users, and promote the intelligent development of university library through these strategies.