This paper studies a specific AI large model for the assessment and optimization of resilience in e-commerce enterprises, and discusses how to use artificial intelligence technology to evaluate and enhance the adaptability and resilience of e-commerce enterprises in the face of market uncertainty and risk. First, the concept of resilience of e-commerce enterprises is defined, and a theoretical framework including key dimensions such as adaptability, resilience, transformation and innovation is constructed. Secondly, the scientific selection, performance evaluation, cost analysis and security of AI large models are discussed, and model construction, fine-tuning and training strategies are proposed.Empirical research shows that the model can effectively evaluate the resilience of e-commerce enterprises and provide decision support. Finally, the model deployment and operation maintenance strategies are proposed, and practical suggestions are provided for the practice of e-commerce enterprises.